& Environmental Epidemiology
Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals (PI Chatzi: R01ES030364):
This study is testing the hypothesis that higher levels of persistent chemicals like the DDT metabolite, DDE, that are concentrated in fat, are associated with reduced weight loss and reduced improvement in metabolic health after bariatric surgery. We seek to identify molecular pathways, altered by DDE in fat tissue, that underlie these effects. The goal is to develop a new paradigm for studying effects of persistent chemicals in fat that could ultimately lead to new strategies for treatment and prevention.